Author

Sonia Villapol

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Open access Sep 2026

Female-Biased IL-17–STAT3 Signaling Marks Dementia-Associated Microglial Inflammation in Alzheimer’s Disease

INTRODUCTION Alzheimer’s disease (AD) disproportionately affects women, but the underlying mechanisms are not fully understood. We compare sex-specific molecular changes across AD with and without dementia at single-cell resolution. METHODS We performed sex-stratified single-nucleus transcriptomic analysis of human AD...

Nourhan Abdelfattah, Reece Kang, Dante Jimenez et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Nanomedicine beyond carriers — devices, cells & living therapeutics

This perspective summarizes the current landscape of biomedical nanotechnologies and outlines how their continued evolution positions nanomedicine as an enabling science driving the next generation of therapeutics.

A. Grattoni, Marco M. Paci, Noah Arnold et al. · Biomedical microdevices · 0 citations

#gene editing Open access Aug 2026

Intranasal CRISPR lipid nanoparticles targeting MAPK9 attenuate neuroinflammation after traumatic brain injury

It is demonstrated that intranasal delivery of Iba-1-targeted CRISPR-LNPs enables effective MAPK9 modulation in Iba-1 + myeloid cells within the injured brain and attenuates acute neuroinflammation following TBI.

Göknur Kara, Morgan Holcomb, Asmaa Hijazi et al. · Biomedical microdevices · 0 citations