Author

Sota Yagi

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Open access Oct 2026

Switching ATP-Forming Phosphoryl-Transfer Chemistry With a Restricted Set of Amino Acids.

Restricting amino acid diversity is expected to impair enzyme catalysis, but whether such constraints simply diminish catalytic activity or generate distinct catalytic chemistry remains unclear. We reconstructed an ancestral nucleoside diphosphate kinase (NDK) scaffold using 10 prebiotically plausible residues plus lys...

Sota Yagi, Subrata Dasgupta, Shunsuke Tagami et al. · Angewandte Chemie · 0 citations

Open access Jul 2026

Prebiotic cationic amino acids support formation of an ancient protein fold

Crystallographic analysis revealed that both this peptide and its Dab-substituted derivative adopted the double-Z β-barrel (DZBB) fold, a likely evolutionary intermediate between extant β-barrel folds, which might have supported the foldability of primitive proteins before the incorporation of lysine and arginine into...

Sota Yagi, Aditya K. Padhi, Khushboo Bhagat et al. · bioRxiv · 0 citations