Crystallographic analysis revealed that both this peptide and its Dab-substituted derivative adopted the double-Z β-barrel (DZBB) fold, a likely evolutionary intermediate between extant β-barrel folds, which might have supported the foldability of primitive proteins before the incorporation of lysine and arginine into the genetic code.
A central question in origin-of-life research is how biological macromolecules and cellular structures arose from simple precursors under prebiotic conditions. This review focuses on the chemical evolution model of N-phosphoryl amino acids (NPAAs) and their multifaceted roles in this process. Featuring high-energy P–...
Jianxi Ying, Yan Liu, Songsen Fu et al.· Accounts of Chemical Researc...· 0 citations
This study proposes that aaRSs can recognize halogenated ncAAs through halogen bonding (XB), and confirms that ncAA recognition by aaRSs occurs through XB, and shows that XB can serve as a driving force for expanding the genetic code with ncAAs.
Surendar R Jakka, Sandhya Jaiswal, K. M. Reddy et al.· Angewandte Chemie· 0 citations
Using NMR spectroscopy, it is shown that three peptides adopt stable, well-defined folded structures in concentrated sulfuric acid, an extreme solvent environment that has been long assumed to be incompatible with biomolecules.
Jia-Yi Zhang, A. Dregni, J. Petkowski et al.· Proceedings of the National...· 0 citations
This is the first experimental demonstration of the link between the Miller-Urey experiment which produced amino acids from elemental starting material, and cell-like structures, and the characterised peptides which form reproducibly, into structures with longevity and which subsequently catalyse the polymerisation of...
S. ten Have, Ewan McMillan, Tim Medway et al.· bioRxiv· 0 citations
The potential of BpyAla-mediated nucleic acid cleavage is discussed, with emphasis on the development of next-generation BpyAla analogues, the exploration of alternative metal cofactors, cooperative and multi-residue design strategies, and the expansion of compatible protein scaffolds and nucleic acid substrates.
Eryn Lundrigan, Matthew T. O'Neill, J. P. Pezacki· Frontiers in Chemical Biolog...· 0 citations
It is suggested that CAP serves as an evolutionary bridge, linking primordial geochemical conditions to the emergence of functional biochemical machinery, and can be generated in situ directly from early-Earth accessible precursors, urea and orthophosphate.
Xiangxiao Zheng, Fude Chen, Min Zhang et al.· Communications Chemistry· 0 citations
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