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Author

S. Nayak

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Oct 2026

Pharmacokinetic, Antimicrobial, Antibiofilm, and Virulence Target Binding Propensities of a Hetero-Ligated Thiolato-Bridged Dinuclear Metallacyclic Manganese(I)-based CO-Releasing Molecule.

Staphylococcus aureus and Escherichia coli remain major concerns in global public health, posing clinical challenges due to their adaptability, virulence, and biofilm-mediated persistence. The continued emergence of drug-resistant strains necessitates the development of new antimicrobial compounds. In this study, we ev...

Aswathy Anil, Meyappan Vadivel, Sriram Shankar et al. · 0 citations
Jul 2026

Simultaneous induction of apoptosis and ferroptosis by a novel thiolato-bridged manganese(I)-based CO-releasing molecule in pancreatic and prostate cancer cells.

It is established that S-MnC is a potent, dual-action therapeutic agent that mediates both apoptosis and ferroptosis, offering a promising strategy to overcome drug resistance in aggressive, metastatic cancers and to enhance therapeutic efficacy.

Aswathy Anil, Diksha Tripathi, S. Nayak et al. · 0 citations
Open access Jul 2026

Pharmacological potential of the marine peptide cyclo(L-phenylalanyl-L-prolyl) against both multidrug-resistant, gram-negative Acinetobacter baumannii and gram-positive Staphylococcus aureus: structure – activity relationship, computational and experimental studies

The experimental and computational findings suggest that cFP is a promising antimicrobial lead and warrant further mechanistic and translational investigation.

Sriram Shankar, Meyappan Vadivel, U. Kumar et al. · 0 citations

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