Pharmacological potential of the marine peptide cyclo(L-phenylalanyl-L-prolyl) against both multidrug-resistant, gram-negative Acinetobacter baumannii and gram-positive Staphylococcus aureus: structure – activity relationship, computational and experimental studies
The experimental and computational findings suggest that cFP is a promising antimicrobial lead and warrant further mechanistic and translational investigation.
Molecular docking results provided a molecular basis for the conjugate's interaction with target proteins (PDB IDs: 4LFU and 4TQX), suggesting its potential as a quorum-sensing modulator.
Findings highlight haloarene-decorated tetrahydropyridine derivatives as promising dual-action candidates with potential to combat both bacterial and malarial infections.
Bhavesh S. Hirani, Mohammad Murwih Alidmat, L. Hasoun et al.· Scientific Reports· 0 citations
4-pentenoic acid showed broad-spectrum activity against 21 strains of pathogenic bacteria, and the combination of 4-pentenoic acid with antibiotics exerted additive antibacterial effects, providing theoretical and experimental basis for the development of new food preservatives and antibacterial agents.
Jiaming Mu, Jie Li, Fu-Shuang Duan et al.· Journal of food microbiology· 0 citations
The hybrids presented here represent promising multifunctional leads with antibacterial, antioxidant, anti‐inflammatory, and drug‐like properties, including Lipinski compliance, high GI absorption, no BBB penetration, and low predicted toxicity.
Mlis Belete, Endale Mulugeta, Daniel Rentsch et al.· ChemistryOpen· 0 citations
In an effort to diverge from the molecular framework of conventional drug molecules, a series of pyrrolo[3,4-d]isoxazolidine-naphthalimide hybrids have been synthesized via a 1,3-dipolar cycloaddition reaction between azomethine N-oxides and N-substituted maleimide, with the aim of exploring moieties capable of lesseni...
A. Jain, Kamaldeep Paul· Journal of materials chemist...· 0 citations
The results identify SH1 as a previously uncharacterised antibacterial agent active against MRSA and support the anthraquinone–DLC pharmacophore as a membrane-active scaffold warranting further structural optimisation.
Victor Arinze Orajekwe· Journal of applied chemical...· 0 citations
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