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Author

Şule Haskoloğlu

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3 papers indexed here

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Review Oct 2026

Immune Checkpoint Dysfunction Remodels Adaptive Immune Receptor Repertoires in CTLA-4 Insufficiency and LRBA Deficiency

It is demonstrated that inherited disruption of the CTLA-4/LRBA axis profoundly remodels AIRRs, preferentially affecting CD8⁺ T-cell diversity while also constraining humoral immunity, and highlight a central role for this immune checkpoint pathway in maintaining adaptive immune repertoire diversity and clonal homeosta...

Gökhan Cildir, Selin Cildir, Rahmi Kutay Erdogan et al. · 0 citations
Review Open access Aug 2026

Nuclear Factor Kappa B (NF-κB)1 and NF-κB2 Deficiency: An Unpredictable Defect With Wide Clinical and Immunologic Phenotype.

The Nuclear Factor Kappa B (NF-kB) signalling pathway is essential for regulating inflammation, cell survival, and adaptive immune responses through its canonical (NF-κB1-associated) and noncanonical (NF-κB2-associated) branches. The canonical pathway mediates rapid and broad reactions to immune stimuli, whereas the no...

Selin Sevinç, Candan Islamoğlu, Şule Haskoloğlu et al. · 0 citations
Case report Aug 2026

A novel FLNA p.Pro2469Ser variant is associated with impaired T and NK cell function and immune dysregulation

Findings indicate that the FLNA p.Pro2469Ser variant identified in a pediatric patient presenting with recurrent infections and inflammatory manifestations is associated with altered immune-cell signaling, disturbed cortical cytoskeletal organization, and immune dysregulation.

Ş. Erdem, A. Kısaarslan, M. B. Acar et al. · 0 citations

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