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TPGS–pyrimethamine micelles enhance cellular uptake and are associated with increased ROS generation, apoptosis, and cell-cycle alterations in MDA-MB-231 cells, together with tumour suppression in a murine lymphoma model, which support further preclinical investigation of TPGS-based pyrimethamine micelles as a potentia...
The identification of marine-derived compounds addresses the need to overcome resistance to single-checkpoint immunotherapy and are regarded as earlystage lead scaffolds requiring structural optimization rather than hits with acceptable overall safety profiles.
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