Structures of pUG-fold RNA bound to DNMT1 reveal a mechanism for RNA-mediated epigenetic regulation
This study provides the first structural basis for pUG- fold RNA recognition by a protein and illustrates how cryo-EM and AI-based methods for protein and RNA structure prediction synergize to inform the mechanism of RNA-mediated regulation of DNMT1.
Jessica J. Song, T. Cech, V. Kasinath
· bioRxiv · 0 citations