Author

T. Giessen

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Open access Aug 2026

A permeable protein nanocage enables facile cargo loading and cytosolic protein delivery

The cytosolic delivery of therapeutic proteins remains one of the most persistent challenges in modern drug delivery. Here, we report the discovery and characterization of an encapsulin-based protein nanocage, QtEnc, with unexpected permeability properties and the ability to internalize cargo proteins in vitro, fundame...

Se-Geun Kwon, Michael P. Andreas, Jesse A. Jones et al. · Nature Communications · 0 citations

Jul 2026

Bacterial Geosmin Biosynthesis is Compartmentalized Inside a Two-Component Protein Shell

It is shown that GeoA cargo loading is mediated by repeating, short cargo loading peptides (CLPs), and that GeoA encapsulation provides benefits for enzyme activity and stability, and provides insights into a putative mode of cargo protein regulation via pore state modulation.

A. Fazal, Cassandra A. Dutcher, Michael P. Andreas et al. · bioRxiv · 0 citations