TL;DR
It is shown that GeoA cargo loading is mediated by repeating, short cargo loading peptides (CLPs), and that GeoA encapsulation provides benefits for enzyme activity and stability, and provides insights into a putative mode of cargo protein regulation via pore state modulation.
Eleven novel core-core interactions and one shell-core interaction across five distinct, previously underexplored types of glycyl radical enzyme-associated (GRM) BMCs are identified, providing new insights into the mechanisms underlying BMC core assembly.
It is shown that cellulosomal principles can operate in highly reduced cohesin‐dockerin systems, and two additional candidate interacting partners for ClcC appear to bind via a non‐canonical interface.
A new class of fungal biosurfactant proteins is introduced and a simplified downstream process based on methanol/chloroform extraction is developed, reducing costs while preserving functionality.
It is revealed that Pandoraea species, including environmental isolates and opportunistic pathogens typically acquired from the environment, produce bifunctional lipopeptides that undergo enzymatic remodeling to switch from promoting bacterial motility to optimizing iron capture.
Functional analysis of the condensation domain in vivo demonstrated that it is essential for clavaic acid biosynthesis, and expands the understanding of LovB-like iPKSs and establishes this enzyme family as a promising source of cryptic fungal polyketides.
Elucidating the mechanisms that generate this diversity, and the multifaceted roles that terpenoids play in plant ecology and physiology not only deepens the understanding of the evolutionary history of terrestrial plants, but also unlocks new opportunities for biotechnological innovation.
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