Author

T. Wiegand

2 papers indexed here

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Open access Sep 2026

Structural and genetic dissection of RNA-guided gene repression by TnpB-derived transcription factors

TnpB nucleases, the evolutionary progenitors of CRISPR-associated Cas12 enzymes, are transposon-encoded, RNA-guided endonucleases found throughout bacteria. Independent of the trajectory towards adaptive immunity, TnpB nucleases have also recurrently given rise to TnpB-like nuclease-dead repressors (TldRs), a family of...

R. Xiao, Americo A. Casas-Ciniglio, Ho-Ang C. Le et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

Targeted Genetic Knockout of Can f 1, the Major Allergen in Dogs.

It is demonstrated that targeted genetic knockout of the major dog allergen is compatible with canine development and can abolish the IgE-mediated allergic response, supporting the feasibility of a gene-based approach to reducing canine allergenicity.

Matt W. G. Walker, Carol Margolis, T. Wiegand et al. · The CRISPR Journal · 0 citations