Author

T. Yankeelov

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#protein folding Open access Nov 2026

Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood-brain barrier after a traumatic brain injury.

These collective findings reveal a counterintuitive finding that I.C.C.V. clindamycin enhances drainage of toxins from the brain while simultaneously restoring the BBB, potentially providing a new solution for alleviating secondary pathogenesis in brain-injured patients.

Landon S. Ashby, Megan G. Crowe, Daveraj Chakravarty et al. · Proceedings of the National... · 0 citations

Open access Jul 2026

Patient-Specific Computational Framework to Spatiotemporally Forecast Treatment Response and Identify Biologically Informed Radiotherapy Targets in High-Grade Glioma

Purpose High-grade gliomas exhibit substantial spatial and temporal heterogeneity, posing a challenge for radiotherapy (RT) target definition. Adaptive RT, which prospectively modifies treatment plans, may benefit from early identification of intratumoral regions likely to exhibit differential treatment response. Appar...

Sophia Ty, Jeanne Kowalski, B. Panthi et al. · JCO Clinical Cancer Informat... · 0 citations

Open access Sep 2026

The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology

Quantitative co-clinical imaging provides a powerful framework to link genotype with function by confirming drug delivery, target engagement, pharmacodynamic effects, tumor function and heterogeneity across animal models and patients to advance functional precision medicine (FPM).

K. Shoghi, C. Badea, Donna M. Peehl et al. · Clinical Cancer Research · 0 citations