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Open access Sep 2026

Calcitriol alleviates ARID2-deficient gastric cancer metastasis via inhibition of the Wnt/β-catenin signaling pathway

Highlights • ARID2 mutation promotes the metastatic capability of GC.• Disruption of ARID2-VDR interaction activates Wnt/β-catenin signaling pathway.• VDR activation prevents ARID2-deficient GC metastasis by blocking nuclear β-catenin.• Calcitriol may represent a therapeutic candidate for ARID2-deficient GC metastasis.

Bi-Ying Liu, Zhao-Le Chu, Yi-Xian Fan et al. · 0 citations
Open access Sep 2026

P4HA3 promotes gastric cancer cell proliferation and invasion via the PI3K/AKT/mTOR signaling pathway and regulates glycolytic metabolic reprogramming

Abstract: Background: Dysregulated expression of prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been identified in Colon cancer, breast cancer, head and neck cancers, etc. and is closely associated with tumor progression. However, its specific roles in gastric cancer (GC), particularly regarding alterations in metabo...

Tao Wang · 0 citations

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