Calcitriol alleviates ARID2-deficient gastric cancer metastasis via inhibition of the Wnt/β-catenin signaling pathway

Abstract

Highlights • ARID2 mutation promotes the metastatic capability of GC.• Disruption of ARID2-VDR interaction activates Wnt/β-catenin signaling pathway.• VDR activation prevents ARID2-deficient GC metastasis by blocking nuclear β-catenin.• Calcitriol may represent a therapeutic candidate for ARID2-deficient GC metastasis.