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Author

Tatsuya Niwa

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#protein folding Open access Sep 2026

Adaptability of the GroEL/GroES chaperonin to proteostatic challenge revealed by directed evolution.

The folding of newly synthesized proteins is assisted by an essential network of proteins known as molecular chaperones. In bacteria, the chaperones Trigger Factor (TF), DnaK/DnaJ (Hsp70 system), and GroEL/GroES (chaperonin system) are key players in proteostasis maintenance. Here, we further explore the cooperation an...

Marie-Pierre Castanié-Cornet, Tatsuya Niwa, É. Dupuy et al. · 0 citations
Open access Jul 2026

Upstream non-AUG initiation and ribosomal −1 frameshifting in ATXN8OS CTA/CTG repeat-associated translation

Abstract Microsatellite repeat expansions contribute to the pathogenesis of many neurodegenerative disorders. In spinocerebellar ataxia type 8 (SCA8), abnormal expansion of CTA/CTG repeats in the 3′ untranslated region of the ATXN8OS (ATXN8 Opposite Strand) gene has been implicated in disease pathology. Although the oc...

Soyoka Sakamoto, Hayato Ito, Mayuka Hasumi et al. · 0 citations

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