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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Taufiq Rahman

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Open access Aug 2026

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is permeable to Ca2+ when activated b...

Qian-Ru Mu, Ryo Saito, Franceska Ozola et al. · 0 citations
#protein folding Open access Aug 2026

Benchmarking protein-ligand co-folding across Nav, Cav and Kv-family channels

Results show that current co-folding methods remain unreliable as stand-alone predictors of ion-channel ligand-binding modes and highlight pose sampling, pocket selection, ligand representation and independent structural validation as priorities for methodological development.

Yu Zhu, Taufiq Rahman · 0 citations

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