ABSTRACT Adjuvants can enhance the elicited immune responses to recombinant hemagglutinin (HA) proteins following intramuscular vaccination. In this study, computationally optimized broadly reactive antigen (COBRA) designed HA proteins were adjuvanted with the W805EC oil-in-water nanoemulsion (“NE01”) and used to vacci...
Matthew H. Thomas, Ted M. Ross· Human Vaccines & Immunothera...· 0 citations
Pentavalent COBRA HA/NA intranasal vaccination adjuvanted with c-di-AMP induced strong humoral and cellular immune responses in murine models, highlighting the value of combining broadly protective COBRA vaccine candidates with advanced mucosal adjuvants to enhance efficacy against antigenically drifted influenza virus...
Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al.· Frontiers in Immunology· 0 citations
This ex vivo primary ferret nasal epithelial cell and peripheral blood mononuclear cell co-culture model shows that signaling decoupling across the "epithelial-immune bridge" drives suboptimal IBV immunogenicity.
These findings demonstrate that COBRA HA encoding mRNA vaccines can effectively leverage immunological memory while expanding responses to conserved HA epitopes, supporting improved protection against antigenically drifted strains and represents a promising strategy for next-generation influenza vaccination.
James D. Allen, Jessica M. Medina, Camila Caetano et al.· bioRxiv· 0 citations
It is demonstrated that an integrated generation–selection strategy can enhance vaccine coverage across current and future A(H3N2) seasons and may be applicable to other influenza subtypes.
Victoria R. Howard, James D. Allen, Matthew H. Thomas et al.· bioRxiv· 0 citations
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