AncientProteinScripts
Code accompanying the paper "Ancient amino acid sets enable stable protein folds" (Giacobelli, Andersson, et al., bioRxiv 2025, doi:10.1101/2025.10.29.685319). Contents: Protein design pipeline: RFdiffusion backbones, ProteinMPNN sequences restricted to a 10-amino-acid ancient alphabet, and a 20-amino-acid comparison d...