Author

Thamonpan Laocharoensuk

2 papers indexed here

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#gene editing Open access Oct 2026

A genome-wide CRISPR knockout screen identifies host dependency factors and potential viral-induced cell death regulators for porcine deltacoronavirus infection

Porcine deltacoronavirus (PDCoV) is a globally circulating coronavirus of swine that causes severe enteric disease and mortality in neonatal piglets. Its broad host range and zoonotic potential raises concerns about continued spillover into human populations. However, the host factors that govern PDCoV infection remain...

Thamonpan Laocharoensuk, Patricia A. Boley, Rosemary A. Blake et al. · bioRxiv · 0 citations

Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

This work provides the first in vitro and in vivo evidence that the conserved N462 residue in the PEDV Mac1 domain is critical for both ADP-ribose binding and hydrolysis, induces IFN production, and contributes to virulence.

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · Journal of Virology · 0 citations