Author

Thomas C. T. Michaels

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Open access Oct 2026

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer’s disease

Neurotoxic intermediates formed during amyloid-β(Aβ) aggregation are thought to drive Alzheimer’s disease, yet their rarity and transient nature have obscured their identity and formation pathways in the human brain. Here, we combine super-resolution microscopy and single-molecule functional imaging with kinetic modell...

Agnieszka Urbanek, A. Dear, David P. Rhodes et al. · bioRxiv · 0 citations

Open access Aug 2026

Theory for Biomolecular Catalysis in Phase-Separated Systems

Enzymatic reactions in biomolecular condensates are often assumed to be regulated through local enrichment of reactants. However, condensates also reshape molecular transport and reaction kinetics, making it unclear how phase separation controls catalysis in living cells. Here, we develop a quantitative theory of biomo...

Gaetano Granatelli, Samuel S Gomez, Sudarshana Laha et al. · bioRxiv · 0 citations

Open access Sep 2026

Weak interactions drive selective proteome demixing and tune the differential response to environmental perturbations

QuPID-MS, which measures the propensity of proteins to phase separate in native cell extracts proteome-wide, finds that weak interactions drive condensation of half of the proteome in a crowding- and temperature-dependent manner and presents evidence that this proteome demixing occurs in cells.

Guido Narduzzi, Federico Zucca, Leo Willig et al. · bioRxiv · 0 citations