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Weak interactions drive selective proteome demixing and tune the differential response to environmental perturbations

Guido Narduzzi Federico Zucca Leo Willig L. Gillet I. Karemaker Aleksander A. Rebane Alba Tomàs Sitjes Leon Young Moritz Becker Simone Reber Thomas C. T. Michaels P. Picotti Gabriel E. Neurohr
Sep 2026 · bioRxiv · 0 citations · 97 references
Biology

TL;DR

QuPID-MS, which measures the propensity of proteins to phase separate in native cell extracts proteome-wide, finds that weak interactions drive condensation of half of the proteome in a crowding- and temperature-dependent manner and presents evidence that this proteome demixing occurs in cells.

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