Author

Thomas S Scanlan

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Open access Aug 2026

The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice

The results suggest that the cognitive-enhancing effects of Sob-AM2 are not the result of reduced overall plaque burden, and future work is needed to further investigate the neuroprotective mechanism of Sob-AM2 and how it may be affecting microglial phenotypes.

Lucas Kuhnau, Gisselle A. Jimenez, Wyatt Hack et al. · bioRxiv · 0 citations

Open access Jul 2026

Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in primary neuronal cultures

It is indicated that elunetirom and LL- 340001 engage complementary neuroplasticity and mitochondrial biogenesis-related programs in neuronal systems and support further investigation of brain-targeted thyromimetic signaling as a mechanistically differentiated approach for major depressive disorder and bipolar depressi...

Jason R. Harris, Jill Baccei, W. Stratton et al. · bioRxiv · 0 citations