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Thomas Spangenberg

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3 papers indexed here

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Open access Oct 2026

From Enzyme to Parasite: Enzymatic and Phenotypic-Guided Evaluation of Repurposed Inhibitors against Schistosoma mansoni cathepsin D1 ( Sm CD1)

Schistosomiasis remains a major public health concern in endemic regions, with treatment relying almost exclusively on praziquantel (PZQ). Although vital, PZQ shows limited activity against immature parasites and raises potential resistance concerns. In this context, Schistosoma mansoni cathepsin D1 (SmCD1), an essen...

B. F. Gomes, L. Gomes, R. F. Dantas et al. · 0 citations
Open access Oct 2026

Modeling the potential effect of cabamiquine-pyronaridine for chemoprevention against Plasmodium falciparum malaria

ABSTRACT Preventive treatment (chemoprevention) is a key intervention for reducing the burden of Plasmodium falciparum malaria in children. The impact of the current widely used drug combination, sulfadoxine-pyrimethamine-amodiaquine (SP-AQ), is challenged by emerging drug resistance and adherence to multi-day dosing....

Lucy C. Okell, Perrine Courlet, F. Venezia et al. · 0 citations
#protein folding Open access Sep 2026

In vitro pharmacodynamics of the antimalarial drug cabamiquine

In vitro findings help contextualize why the clinically observed lag in parasite clearance may be temporally distinct from symptomatic improvement, including fever resolution, and present cabamiquine as a fast-acting, slow clearing antimalarial drug.

Claudia Demarta-Gatsi, J. Wallner, S. K. Dhingra et al. · 0 citations

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