Author

Tian-Hua Wang

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Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

Serotonin (5-HT) is critical for neurodevelopment, influencing brain maturation, emotional regulation, and social behavior. Tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme for central 5-HT synthesis, causes lifelong 5-HT depletion when disrupted. While early-life 5-HT perturbations are linked to neuropsyc...

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations

Open access Aug 2026

GluD1 Modulates GluN2B-containing NMDAR Function and Plasticity at Subicular Synapses

It is demonstrated that GluD1 is indispensable for preserving GluN2B-containing NMDAR function, synaptic plasticity, and memory, providing molecular insight into how GluD1 regulates NMDAR subtypes implicated in synaptic dysfunction in neuropsychiatric disorders.

Eric Purisic, Darielle Lewis-Sanders, Marian Zhong et al. · bioRxiv · 0 citations