GluD1 Modulates GluN2B-containing NMDAR Function and Plasticity at Subicular Synapses

A cell type-specific switch in GluN2D NMDA receptors drives cortical circuit hyperexcitability and sensory-driven cortical synchronization deficits in a Fragile X Syndrome model.

BACKGROUND Altered sensory processing and sensitivity are prevalent in Fragile X Syndrome (FXS) and may be mediated by dysfunction of cortical circuits. Evidence from individuals with FXS and/or the FXS mouse model, Fmr1 KO, indicates hyperexcitability of sensory cortical circuits, deficits in sensory-driven circuit sy...

Hippocampal LTP shifts from NMDAR dependence to mGluR/VGCC-supported mechanisms following juvenile status epilepticus in rats.

Hippocampal long-term potentiation (LTP) can persist in the chronic epileptic state, but the mechanisms supporting this residual plasticity remain poorly understood. In particular, it is unclear whether LTP retains canonical N-methyl-D-aspartate receptor (NMDAR) dependence or shifts to alternative induction mechanisms....

GABAB Receptors Gate Sex-Specific Synaptic Plasticity in the Nucleus Accumbens

Excitatory synaptic plasticity within the nucleus accumbens (NAc) drives motivated behaviors, and dysregulation is implicated in several psychiatric disorders marked by impaired reward processing. The NAc integrates glutamatergic input, which conveys information about reward, context, and behavioral goals, with local G...

Neuronal glutamate transporter EAAT3 regulates hippocampal GABAergic plasticity and reversal learning

Glycine Transporter 1 Inhibitor, Bitopertin, Changes Excitatory and Inhibitory Network Connectivity in Mouse Medial Prefrontal Cortex.

It is found that bitopertin chiefly impacts the inhibitory network, while minimally affecting PNs, and this insight could aid the development of more effective therapies for cognitive dysfunctions caused by E/I imbalance.

Reduction in membrane AMPA receptor subunit 2 in left prefrontal cortex correlates with post-stroke depression

Post-stroke depression (PSD) is a prevalent and debilitating complication of stroke. While ischemic lesion in left prefrontal cortex (PFC) is a recognized risk factor, the underlying mechanisms linking this locus to PSD remain poorly defined. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subu...