Tian-Tian Wang

Ultrasound-Synchronized In Situ Crystallization Locks Transient High-Activity Enzyme Conformations within Covalent Organic Frameworks

Enzymes transiently access high-activity conformations with exposed cryptic sites and heightened substrate affinity, yet these states dissipate upon relaxation to the thermodynamic ground state once the activating perturbation is removed, leaving this catalytic potential largely inaccessible. Here we show that such f...