Engineered Transformer Base Editor with Enhanced Editing Efficiency
The engineered tBE (etBE) exhibited substantially enhanced editing efficiencies compared with the parental tBE, while maintaining high editing fidelity and background levels of OT mutations, and represents a highly efficient and specific base editing platform with enormous potential for both basic research and clinical...
Bo-Wen Chen, Le-Tong Liang, Ruijuan Xu et al.
· Advancement of science · 0 citations