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Tie-Gang Han

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Open access Sep 2026

43 DSG2 and NPNT are Elevated in the Plasma of Metastatic Chromophobe RCC and are Associated with Poorer Overall Survival

Abstract Background Chromophobe renal cell carcinoma (ChRCC) is traditionally defined by its unique metabolic reprogramming, including an increase in mitochondrial mass. The mitochondrial plasma proteome of metastatic ChRCC has been recently reported (Steiner et al. Cancers 2026), and we defined a two-protein signature...

Tie-Gang Han, Clara Steiner, Steven Safi et al. · 0 citations
Open access Sep 2026

42 Spatial Mapping of the Sarcomatoid Transition in Chromophobe Renal Cell Carcinoma Reveals a Reprogrammed Tumor-Immune Interactome

Abstract Background Chromophobe Renal Cell Carcinoma (ChRCC), derived from the intercalated cells of the collecting duct, typically follows an indolent clinical course. However, approximately 5–8% of cases undergo sarcomatoid transformation (sChRCC), a high-grade dedifferentiation resulting in a spindle-cell morphology...

Yan Tang, Tie-Gang Han, K. Collins et al. · 0 citations

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