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Timothée Lionnet

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#protein folding Oct 2026

Generative design of functional disordered regions in a developmental transcription factor

Rapid advances in protein structure design have not translated to intrinsically disordered regions (IDRs). This is largely due to our incomplete understanding of how IDR sequence encodes function. Here, we use stem cell differentiation as a model to map functional sequence features in the IDR of transcription factor RU...

Lance T. Denes, Ryan J. Emenecker, Nongyun Wang et al. · 0 citations

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