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#protein folding Review Open access Nov 2026

From structure prediction to ligand–target recognition: expanding the reach of AlphaFold in natural product research

Natural products constitute a structurally diverse reservoir of bioactive molecules and remain an important source of lead compounds for drug discovery. However, the limited availability of structural information on pharmacological targets and biomolecular interactions continues to hinder mechanism elucidation and stru...

Guang-Rui Xu, Hai-Feng Hu, Wei-Hui Zhao et al. · 0 citations
Review Jul 2026

SIRT6, a New Hope in Liver Diseases: From Pathogenic Mechanisms to Therapeutic Strategies.

The liver is a vital organ in the human body, responsible for multiple functions, including immunity, digestion, detoxification, and vitamin storage. Liver diseases cause approximately 2 million deaths annually, accounting for 4% of global mortality, making it a worldwide health challenge. The NAD⁷-dependent deacetylas...

Zheng-Xi Liu, Qi-qi Huang, Xiao-xun Cong et al. · 0 citations

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