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Author

Tomek Swigut

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Open access Sep 2026

Enhancer Tuning by Sequence-Specific Repressors

It is proposed that SNAI1/2 function as a molecular dimmer switch—modulating nucleosome dynamics to calibrate enhancer output to achieve precise spatiotemporal control of transcript dosage.

Lucia Ichino, Kaelan J. Brennan, Ben Mallory et al. · 0 citations
Jul 2026

Promoter strength and position govern promoter competition through transcript-dependent insulation

The rules governing promoter competition are uncovered, its impact on tuning gene expression levels and genome evolution is highlighted, and it is suggested that transcriptional units producing transcripts of sufficient level and length can mediate insulation independently of CTCF and cohesin.

Mervenaz Koska, Masahiro Nagano, Tomek Swigut et al. · 1 citation

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