Author

V. Kasinath

2 papers indexed here

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Open access Sep 2026

Structures of MeCP2 bound to nucleosomes reveal distinct mechanisms of Rett syndrome mutations

This work establishes a framework linking variant-specific defects in nucleosome binding to chromatin-targeting failure and transcriptional dysregulation in RTT.

Li-Qi Yao, Carolina Valderrama-Hincapié, Jia-Rui Song et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Structures of pUG-fold RNA bound to DNMT1 reveal a mechanism for RNA-mediated epigenetic regulation

This study provides the first structural basis for pUG- fold RNA recognition by a protein and illustrates how cryo-EM and AI-based methods for protein and RNA structure prediction synergize to inform the mechanism of RNA-mediated regulation of DNMT1.

Jessica J. Song, T. Cech, V. Kasinath · bioRxiv · 0 citations