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V. Solovyeva

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Review Open access Sep 2026

Biotechnological and Cellular Therapies in the Treatment of Neurodegenerative Leukodystrophies

Leukodystrophies are inherited neurodegenerative disorders characterized by progressive white matter damage, historically lacking effective treatments beyond symptomatic management and hematopoietic stem cell transplantation. This review analyzes contemporary biotechnological strategies, including gene therapy, cell-ba...

A. I. Ayupova, Tatiana S. Tsaregorodtseva, V. Solovyeva et al. · 0 citations
Review Open access Jul 2026

Current Aspects of Cellular Immunotherapy for Melanoma

An analysis of clinical trial data shows that combination approaches that combine cellular therapy with immune checkpoint inhibitors or standard treatments are the most effective, highlighting the need for further research in personalized immunotherapy for melanoma.

Chulpan B. Kharisova, A. Gorodilova, Y. Mayasin et al. · 0 citations
#gene editing Review Open access Aug 2026

Genetically Modified MSCs for Targeted Regeneration: Balancing Efficacy, Biosafety, and GMP Standardization

Development of safe-harbor integration and B2M/CIITA-based hypoimmunogenic designs as strategies to reduce engineering-related batch variability and HLA-dependent donor variability support a transition from empirical optimized MSC preparations toward molecularly defined cellular medicines with predefined genotype, expr...

Kristina V. Kitaeva, I. Filin, A. Rizvanov et al. · 0 citations
Review Open access Aug 2026

Application of Mesenchymal Stromal Cells and Their Exosomes in Neurodegenerative Diseases and Lysosomal Storage Diseases

This review provides a roadmap for translational decision-making and identifies critical gaps that must be addressed before MSC-based therapies can be integrated into routine neurological practice.

A. I. Ayupova, Angelina S. Sidorova, Ekaterina A. Luzina et al. · 0 citations

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