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Author

Veysel Kayser

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#protein folding Open access Oct 2026

Polar vs Non-polar Excipients in BSA Aggregation.

PURPOSE In recent years, there has been a rapid expansion in the development of new protein therapeutics in the pharmaceutical industry. Problematically, proteins are conformationally and colloidally marginally stable, and thus it is necessary to formulate them using buffering and stabilizing agents. METHODS In this...

Samuel Tien, Simone Nørgaard Krabbe, Annika Sollann Sørensen et al. · 0 citations
Aug 2026

Conformational Ensemble and Stabilization of Insulin by a Choline Ionic Liquid Elucidated through Markov State Models.

Proteins in solution continually fluctuate between conformational states, and these dynamics play a central role in their structural and colloidal stability. Using molecular dynamics simulations, we show that insulin exists as a conformational ensemble in solution, which can be quantitatively described using a Markov s...

Samuel Tien, T. Balle, S. Kuyucak et al. · 0 citations

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