Rethinking Alzheimer's: Why Neurodegeneration Begins at the Physical Boundary, Not with Protein Plaques
Decades of clinical trials targeting amyloid-beta plaques and tau tangles have yielded minimal therapeutic reversal in Alzheimer’s disease. Recent structural biology demonstrates that by the time macroscopic protein aggregates appear, the neuron’s fundamental information-processing highway—the microtubule lattice—has a...