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Author

Vinay Sharma

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Open access Aug 2026

NLRC5 restricts Japanese encephalitis virus replication and neuroinflammation by interacting with the viral NS3 protein in an IFN-γ-dependent manner

It is demonstrated that NLRC5 functions as a cell-type-specific antiviral regulator during JEV infection and suppresses viral replication by directly binding to and degrading the viral NS3 protein in an LRR-dependent manner.

Prasanjit Jena, Rohit Soni, Abhigya Chhetri et al. · 0 citations
Aug 2026

Crystal structure of pilus-specific sortase from Enterococcus faecalis reveals both open and closed conformations: insights into loop dynamics and substrate recognition.

The unprecedented structural snapshots of both open and closed lid conformations, synchronized with the proline switch in the β7-β8 loop, captured in the same crystal structure, advance the understanding of sortase-mediated virulence in enterococci and provide a framework for the development of antivirulence strategies...

Vinay Sharma, Sumit Murmu, Rajendra Prasad Roy et al. · 0 citations

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