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Author

Vittoria Scapin

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Open access Oct 2026

Thrombin reshapes α-synuclein biochemical properties by N-terminal truncation

Proteolytic processing of α-Synuclein (Syn) contributes to the molecular diversity and toxicity of its aggregates in Parkinson’s disease, yet the proteases responsible for disease-relevant truncations remain incompletely defined. Here, we show that thrombin, a serine protease associated with inflammatory conditions,...

Philipp Trolese, Benedetta Fongaro, Alberto Benetollo et al. · 0 citations
Open access Oct 2026

Aromatic amino acid decarboxylase - exploring the structural and functional role of its N-terminal domain using deficiency-associated variants.

Three amino-terminal variants identified in hypoglycemic patients underlie the molecular basis for the clinical variability of AADC deficiency, providing a molecular basis for the clinical variability of AADC deficiency.

Giovanni Bisello, S. K. Uçar, Ayse Yuksel Yanbolu et al. · 0 citations

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