DNA repair requires dynamic control of proteins on single-stranded DNA (ssDNA), yet how ubiquitin signaling regulates ssDNA-bound factors remains poorly understood. Here, we identify in human cells a ubiquitin chain-editing mechanism that promotes extraction of replication protein A (RPA) from ssDNA. We show that RPA s...
Matthew T. Drake, Xian-Zhen Zhou, Alexandra McStea et al.· Molecules and Cells· 0 citations
Coronavirus spike proteins mediate receptor binding and fusion and are key determinants of viral host range. To bind protein receptors, some CoV spikes undergo conformational changes termed opening, which expose the receptor-binding surface. Yet, the prerequisites and mechanism of spike opening remain poorly understood...
John D. Clarke, Michalina Grabias, Antonio di Maio et al.· bioRxiv· 0 citations
LemonCatcher is created, a protein superglue that spontaneously forms an amide bond to the LemonTag peptide under these harsh acidic and cold quench conditions, even at -20 °C, and SelQueX makes possible selective characterization of protein structural dynamics within the complex cellular milieu.
Dietmar Hammerschmid, Mahjoobeh Eshani, A. H. Keeble et al.· bioRxiv· 0 citations
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