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W. K. Scott

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Open access Sep 2026

Unraveling changes in mitochondrial processes influenced by ancestry in APOEε4 carriers with Alzheimer disease

The APOEε4 allele is the strongest known genetic risk factor for late-onset Alzheimer disease (AD). However, the risk effect of APOEε4 varies substantially by ancestry, with individuals of African ancestry (AF) demonstrating markedly lower risk compared to those of European ancestry (EU). This difference in r...

M. D. M. Muniz Moreno, K. Celis, F. Rajabli et al. · 0 citations
Open access Sep 2026

Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish

Heritability estimates suggested that common variants explain much of genetic risk among APOE-{varepsilon}4 carriers, while unexplained heritability remains in non-carriers in the Amish, and GWAS confirmed APOE-{varepsilon}4 as the strongest genetic determinant of AD in the Amish.

Yi-Ning Liu, Yeunjoo E. Song, Wei-Huan Wang et al. · 0 citations

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