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W. Roosens

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Open access Oct 2026

JAK-inhibitor treatment induces rapid yet incomplete immune reconstitution in STAT1 gain-of-function

Iglesias-Herrero et al. longitudinally assess JAK-inhibitor treatment response in two patients with STAT1 gain-of-function and show that it induces rapid but incomplete immune reconstitution, with increased TCR diversity and reversal of monocyte hyperinflammation, highlighting both therapeutic benefit and persistent im...

Cecilia Iglesias-Herrero, W. Roosens, G. Galicia et al. · 0 citations

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