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Aug 2026

SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure

Results demonstrate that SREBF2 mitigates MI-induced HF by activating the Cav-1/PINK1/Parkin axis to promote mitophagy and inhibit ferroptosis, and identify SREBF2 as a promising therapeutic target in heart failure.

Jia Li, Jia Liu, Fan-Yan Luo et al. · 0 citations

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