Synonymous codon choices shape mRNA stability, translation, and folding, and codon language models (cLMs) are increasingly reported to read this biology from sequence. However, when a true signal is thin relative to a confounding one, standard evaluation protocols can manufacture the reported gain rather than measure i...
ProRB is introduced, a unified sequence-based framework that jointly estimates protein–RNA binding affinity, predicts binding interfaces in proteins and RNAs, and generates protein-binding RNA sequences from protein sequences that provides a scalable unified model for decoding the protein–RNA interaction and engineerin...
An RNA design approach, AlignIF, that leverages multiple structure alignment with cross-graph modeling and carefully hand-designed features to capture evolutionarily conserved structural patterns at the structural level, facilitating RNA sequence design outperforms existing state-of-the-art methods in test sets.
Sheng-Fan Wang, Jun Wang, Xiao-Jian Liu et al.· Nature Computational Science· 2 citations· ⚡1
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