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Structure-alignment-driven cross-graph modeling for functional RNA design

Sheng-Fan Wang Jun Wang Xiao-Jian Liu Wei-Min Zhu Jia-Qi Huang Yi-Ming Xue Jun-Chi Yan Hong-Bin Shen Jie Song Xiao-Yong Pan
Jul 2026 · Nature Computational Science · Vol 6, pp. 826 - 841 · 2 citations · ⚡ 1 influential · 62 references
Medicine

TL;DR

An RNA design approach, AlignIF, that leverages multiple structure alignment with cross-graph modeling and carefully hand-designed features to capture evolutionarily conserved structural patterns at the structural level, facilitating RNA sequence design outperforms existing state-of-the-art methods in test sets.

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