Sevoflurane suppresses circ_SMG6 to inhibit TLR4/mTOR signaling and attenuate myocardial ischemia-reperfusion injury
Findings identify circ_SMG6 as a potential therapeutic target in sevoflurane-based cardioprotection against MIRI through TLR4/mTOR-associated inflammatory and apoptotic signaling in cardiomyocytes, while sevoflurane attenuates myocardial injury, at least in part, by suppressing this circ_SMG6-related pathway.