Findings identify circ_SMG6 as a potential therapeutic target in sevoflurane-based cardioprotection against MIRI through TLR4/mTOR-associated inflammatory and apoptotic signaling in cardiomyocytes, while sevoflurane attenuates myocardial injury, at least in part, by suppressing this circ_SMG6-related pathway.
BACKGROUND
Sevoflurane treatment has been shown to effectively alleviate kidney ischemia-reperfusion injury, but the specific mechanism of its renal protective effects is still not entirely understood. This study aimed to uncover the potential mechanisms underlying the renoprotective effect of sevoflurane against ische...
Zhong-Su Wang, Yu-Long Ji, Muhammad Sulaiman et al.· Tissue & Cell· 0 citations
Objective(s): Myocardial ischemia-reperfusion injury (MIRI) lacks effective multi-target interventions. Electroacupuncture (EA) shows cardioprotective potential, but its molecular mechanisms remain incompletely understood. This study aimed to investigate whether EA exerts cardioprotective effects by modulating myocardi...
Han Li, Fang-Fang Mou, Jing-Fa Zhang et al.· Iranian Journal of Basic Med...· 0 citations
Myocardial ischemia–reperfusion injury (MIRI) remains a major complication in acute coronary syndrome and cardiac surgery, with oxidative stress and metabolic dysregulation serving as central pathogenic drivers. This study aimed to clarify whether the novel MyD88 inhibitor TJ-M2010-5 confers cardioprotection against MI...
Bo Wang, Xia Huang, Lin Xie· International Journal of Mol...· 0 citations
Myocardial ischemia-reperfusion injury (MIRI) remains a significant challenge in cardiovascular medicine, and its molecular mechanisms are not yet fully elucidated.
In the present study, integrated transcriptomic analysis combined with machine learning identified PMEPA1 as a key gene consistently downregul...
This article examined the effect of DLX6-AS1 on ischemia perfusion-induced myocardial injury caused by necroptosis and the underlying potential mechanism and identified the possible mechanism by overexpressing and inhibiting DLX6-AS1 expression.
Yan-Ping Su, Li-Ting Mu, Lei Wang et al.· Scientific Reports· 0 citations
