Jul 2026
Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture
A three-dimensional culture model of TPC-1 thyroid cancer cells was developed and identified transforming growth factor beta 1 (TGF-β1) as a potent inducer of thyroid cancer dedifferentiation, establishing TGF-β1 as a therapeutic target in thyroid cancer.
Li Zhang, Wen-Jing Gao, Shi-Chen Xu et al.
· Journal of Endocrinological... · 0 citations