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Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture

Li Zhang Wen-Jing Gao Shi-Chen Xu Hong-Xun Wu Yun Zhu Bo-Tao Huang Xian Cheng Jing Wu Hui-Xin Yu Jian-Dong Bao Zi-Chao Zhang
Jul 2026 · Journal of Endocrinological Investigation · Vol 49, pp. 2693 - 2707 · 0 citations · 58 references
Medicine

TL;DR

A three-dimensional culture model of TPC-1 thyroid cancer cells was developed and identified transforming growth factor beta 1 (TGF-β1) as a potent inducer of thyroid cancer dedifferentiation, establishing TGF-β1 as a therapeutic target in thyroid cancer.

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