Author

Wen Liu

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#protein folding Sep 2026

Leveraging Protein Dynamics for Selective Inhibition of Threonyl-tRNA Synthetase by Obafluorin Analogs.

A structure dynamics-based design strategy is reported that transforms OB into a selective antibacterial agent through rational modification of the nitrophenyl moiety, and establishes a 'kinetic sensor' strategy for achieving species selectivity.

Zilu Wang, Zheng-Xuan Zhang, Mingyu Xia et al. · Angewandte Chemie · 0 citations

Open access Aug 2026

A pyridoxal phosphate-dependent enzyme platform for stereoselective synthesis of γ-tertiary-nitro-noncanonical amino acids

Non-canonical amino acids (ncAAs) are privileged building blocks for the synthesis of natural products, biocatalysts, and drug molecules. Among them, γ-tertiary-nitro-α-amino acids are highly valuable yet remain scarcely explored due to challenges in synthetic accessibility. Although pyridoxal-5′-phosphate (PLP)-depend...

Wen-Ping Ding, Sheng-Gan Luo, Yi-Ke Zou et al. · Nature Communications · 0 citations