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Author

Wenhao Shi

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Sep 2026

De Novo Design of Targeted Drugs by Precisely Programming Multiple Molecular Binding

Targeted drug discovery has enabled the development of effective therapies for many diseases. However, a fundamental challenge remains in translating molecular binding into functional performance for the development of novel targeted drugs. Here, we present a programmable DNA nanoframe (NF) strategy that converts lig...

Chuang-Yuan Zhao, Yu Jin, Xue Li et al. · 0 citations
Aug 2026

CTPS1 promotes lung adenocarcinoma progression as a targetable vulnerability.

Targeting CTPS1 with STP938, alone or in combination with osimertinib, represents a promising therapeutic strategy and supports CTPS1 as a targetable vulnerability in lung adenocarcinoma.

Hui Xie, Cai-Xia Xu, Bing-Han Zhou et al. · 0 citations

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