Integrative ALS therapy: gene targeted therapy by base editing and potential exercise rehabilitation as synergistic strategies for functional recovery
Antisense oligonucleotides and genome editing can restore transcript fidelity by preventing cryptic exons inclusion in STMN2 and UNC13A, thereby stabilizing neuronal function and improving the lifespan and quality of life of patients with ALS.
Kwangjun Lee, Taejin Kwak, Wonil Park
· Physical activity and nutrit... · 0 citations